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Article

SCN5A Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome.

Journal of the American Heart Association - 5 Jun 2017

Makarawate Pattarapong, Chaosuwannakit Narumol, Vannaprasaht Suda, Sahasthas Dujdao, Koo Seok Hwee, Lee Edmund Jon Deoon, Tassaneeyakul Wichittra, Barajas-Martinez Hector, Hu Dan, Sawanyawisuth Kittisak

Abstract excerpt

BACKGROUND: Brugada syndrome (BrS) is an inherited primary arrhythmia disorder leading to sudden cardiac arrest. SCN5A, encoding the α-subunit of the cardiac sodium channel (Nav1.5), is the most common pathogenic gene of BrS. An implantable cardioverter defibrillator (ICD) is the standard treatment for secondary prevention. This study aimed to evaluate association of the SCN5A variant with this cardiac conduction...

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Identifiers

PMID: 28584071
DOI: 10.1161/JAHA.116.005009
PMCID: PMC5669154

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