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Article

A single polymerase (L) mutation in avian metapneumovirus increased virulence and partially maintained virus viability at an elevated temperature.

The Journal of general virology - 1 Feb 2011

Brown Paul A, Lupini Caterina, Catelli Elena, Clubbe Jayne, Ricchizzi Enrico, Naylor Clive J

Abstract excerpt

Previously, a virulent avian metapneumovirus, farm isolate Italy 309/04, was shown to have been derived from a live vaccine. Virulence due to the five nucleotide mutations associated with the reversion to virulence was investigated by their addition to the genome of the vaccine strain using rever...

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Identifiers

PMID: 21048037
DOI: 10.1099/vir.0.026740-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21048037-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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