Article
Predicting genetic predisposition in humans: the promise of whole-genome markers.
Nature reviews. Genetics - 1 Dec 2010
de los Campos Gustavo, Gianola Daniel, Allison David B
Abstract excerpt
Although genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. We propose that alternative approaches, which are largely borrowed from animal breeding,...
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