Article
Tumor suppressor death-associated protein kinase is required for full IL-1β production.
Blood - 20 Jan 2011
Chuang Ya-Ting, Lin Yu-Chuan, Lin Kuan-Hung, Chou Ting-Fang, Kuo Wen-Chih, Yang Kai-Ting, Wu Pei-Rung, Chen Ruey-Hwa, Kimchi Adi, Lai Ming-Zong
Abstract excerpt
Interleukin-1β (IL-1β) is critical for inflammation and control of infection. The production of IL-1β depends on expression of pro-IL-1β and inflammasome component induced by inflammatory stimuli, followed by assembly of inflammasome to generate caspase-1 for cleavage of pro-IL-1β. Here we show that tumor suppressor death-associated protein kinase (DAPK) deficiency impaired IL-1β production in macrophages....
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