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Article

Defining the secondary structural requirements of a cocaine-binding aptamer by a thermodynamic and mutation study.

Biophysical chemistry - 1 Dec 2010

Neves Miguel A D, Reinstein Oren, Saad Makbul, Johnson Philip E

Abstract excerpt

Isothermal titration calorimetry (ITC) was used to measure the binding affinity and thermodynamics of a cocaine-binding aptamer as a function of pH and NaCl concentration. Tightest binding was achieved at a pH value of 7.4 and under conditions of no added NaCl. These data indicate that ionic inte...

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Source

Identifiers

PMID: 21035241
DOI: 10.1016/j.bpc.2010.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21035241-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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