Article
Role of autophagy in diabetes and mitochondria.
Annals of the New York Academy of Sciences - 1 Jul 2010
Jung Hye Seung, Lee Myung-Shik
Abstract excerpt
Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Mitochondrial dysfunction may play a role in both processes of diabetes. Autophagy maintains cellular homeostasis through degradation and recycling of organelles such as mitochondria. As dysfunctional mitochondria are the main organelles removed by autophagy, we studied the role of autophagy in...
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