Article
Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma.
Oral diseases - 1 Apr 2011
Tsai W-C, Lin Y-C, Tsai S-T, Shen W-H, Chao T-L, Lee S-L, Wu L-W
Abstract excerpt
OBJECTIVE: S100A2, a Ca(2+) -binding protein with two EF-hands, is a tumor suppressor in oral cancer. Helix III flanking the C-terminal EF-hand is implicated to participate in the interaction of S100A2 and its target(s). The aim of this study was to examine if the coding sequence polymorphism S100A2_185G>A, leading to the peptide 62 substitution of asparagine (AAC, A allele) for serine (AGC, G allele) in helix...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.