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Article

Sensitivity analysis predicts that the ERK-pMEK interaction regulates ERK nuclear translocation.

IET systems biology - 1 Sept 2009

Radhakrishnan K, Edwards J S, Lidke D S, Jovin T M, Wilson B S, Oliver J M

Abstract excerpt

Following phosphorylation, nuclear translocation of the mitogen-activated protein kinases (MAPKs), ERK1 and ERK2, is critical for both gene expression and DNA replication induced by growth factors. ERK nuclear translocation has therefore been studied extensively, but many details remain unresolved, including whether or not ERK dimerisation is required for translocation. Here, we simulate ERK nuclear translocation...

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Identifiers

PMID: 21028924
DOI: 10.1049/iet-syb.2009.0010
PMCID: PMC3097028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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