Article
The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers.
International journal of clinical pharmacology research - 1 Jan 1990
al-Sereiti M R, Edeki T, Lledo P, Turner P
Abstract excerpt
The effects of a single 20 mg oral dose of timolol, a non-selective beta-adrenoceptor antagonist which is subject to hydroxylation in the liver, on intraocular pressure and heart rate were compared in four poor and five extensive debrisoquine metabolizers, using non-contact tonometry and bicycle ergometry. The beta blockade of timolol on exercise heart rate was significantly higher in poor than in extensive...
Topics
- Adult
- Debrisoquin
- Electrocardiography
- Exercise
- Female
- Heart Rate
- Humans
- Intraocular Pressure
- Male
- Phenotype
- Timolol