Article
EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.
Cancer research - 1 Nov 2010
Chou Yu-Ting, Lin Hua-Heng, Lien Yung-Chang, Wang Yuan-Hung, Hong Chun-Fu, Kao Yu-Rung, Lin Sheng-Chieh, Chang Ying-Che, Lin Shu-Yu, Chen Shu-Jen, Chen Hua-Chien, Yeh Shauh-Der, Wu Cheng-Wen
Abstract excerpt
MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis. In this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells. EGFR activation or ectopic expression of Ras...
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