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Article

Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles.

Virology - 5 Jan 2011

Stahnke Stefanie, Lux Kerstin, Uhrig Silke, Kreppel Florian, Hösel Marianna, Coutelle Oliver, Ogris Manfred, Hallek Michael, Büning Hildegard

Abstract excerpt

The unique region of the VP1 capsid protein of adeno-associated viruses (AAV) in common with autonomously replicating parvoviruses comprises a secreted phospholipase A2 (sPLA2) homology domain. While the sPLA2 domain of Minute Virus of Mice has recently been shown to mediate endosomal escape by l...

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PMID: 20974479
DOI: 10.1016/j.virol.2010.09.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20974479-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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