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Article

REST corepressor (CoREST) repression induces phenotypic gene regulation in advanced osteoarthritic chondrocytes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Dec 2010

Xiao Jun, Li Tao, Wu Zhihong, Shi Zhanjun, Chen Jianting, Lam Stephen K L, Zhao Zandong, Yang Lanbo, Qiu Guixing

Abstract excerpt

Alternations in cartilage chondrocyte phenotype characteristic by the decreased type II collagen and aggrecan together with increased type X collagen synthesis serve as a beacon for osteoarthritis progression. However, little is known about the underlying molecular mechanisms. The current study seeks to discover molecules that involved in osteoarthritic chondrocytes phenotype regulation. Differential proteomics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20973059
DOI: 10.1002/jor.21151

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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