Article
Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.
Pancreas - 1 Jan 2011
Mohelnikova-Duchonova Beatrice, Marsakova Lenka, Vrana David, Holcatova Ivana, Ryska Miroslav, Smerhovsky Zdenek, Slamova Alena, Schejbalova Miriam, Soucek Pavel
Abstract excerpt
OBJECTIVES: Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide...
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