Article
The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2011
Judson Robert N, Wackerhage Henning, Hughes Alun, Mavroeidi Alexandra, Barr Rebecca J, Macdonald Helen M, Ratkevicius Aivaras, Reid David M, Hocking Lynne J
Abstract excerpt
BACKGROUND: Falls among elderly people is a major issue in public health, causing debilitating outcomes including fracture. The identification of genetic risk factors for falling may provide a strategy for effectively targeting falls prevention programs. We investigated whether a common functional variant of skeletal muscle α-actinin-3 (ACTN3 p. R577X) previously associated with impairments in muscle strength,...
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