Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.

doi:10.1086/656811

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Article

Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Nov 2010

Medrano Jose, Neukam Karin, Rallón Norma, Rivero Antonio, Resino Salvador, Naggie Susanna, Caruz Antonio, Calvino Aida, Macías Juan, Benito Jose Miguel, Sánchez-Piedra Carlos, Vispo Eugenia, Barreiro Pablo, McHutchison John, Pineda Juan Antonio, Soriano Vincent

Abstract excerpt

BACKGROUND: A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection. Given that therapy is poorly tolerated and rates of response are lower in patients coinfected with HCV and human immunodeficiency virus (HIV), the recognition of predictors...

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PMID: 20964522
DOI: 10.1086/656811

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