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Article

Nestin is required for the proper self-renewal of neural stem cells.

Stem cells (Dayton, Ohio) - 1 Dec 2010

Park Donghyun, Xiang Andy Peng, Mao Frank Fuxiang, Zhang Li, Di Chun-Guang, Liu Xiao-Mei, Shao Yuan, Ma Bao-Feng, Lee Jae-Hyun, Ha Kwon-Soo, Walton Noah, Lahn Bruce T

Abstract excerpt

The intermediate filament protein, nestin, is a widely employed marker of multipotent neural stem cells (NSCs). Recent in vitro studies have implicated nestin in a number of cellular processes, but there is no data yet on its in vivo function. Here, we report the construction and functional characterization of Nestin knockout mice. We found that these mice show embryonic lethality, with neuroepithelium of the...

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PMID: 20963821
DOI: 10.1002/stem.541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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