Cytokine and Progesterone Receptor Interplay in the Regulation of MUC1 Gene Expression

Abstract excerpt

Mucin 1 (MUC1), a transmembrane mucin expressed at the apical surface of uterine epithelia, is a barrier to microbial infection and enzymatic attack. MUC1 loss at implantation sites appears to be required to permit embryo attachment and implantation in most species. MUC1 expression is regulated by progesterone (P) and proinflammatory cytokines, including TNFα and interferon γ (IFNγ). TNFα and IFNγ are highly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endometriosis Research and Treatment
• Share to Reproductive Physiology in Livestock
• Share to Reproductive System and Pregnancy