Article
Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer.
Molecular cancer - 8 Apr 2015
Koizume Shiro, Ito Shin, Nakamura Yoshiyasu, Yoshihara Mitsuyo, Furuya Mitsuko, Yamada Roppei, Miyagi Etsuko, Hirahara Fumiki, Takano Yasuo, Miyagi Yohei
Abstract excerpt
BACKGROUND: Elucidation of the molecular mechanisms by which cancer cells overcome hypoxia is potentially important for targeted therapy. Complexation of hypoxia-inducible factors (HIFs) with aryl hydrocarbon receptor nuclear translocators can enhance gene expression and initiate cellular responses to hypoxia. However, multiple molecular mechanisms may be required for cancer cells to adapt to diverse...
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