Article
Nucleotide excision repair: variations associated with cancer development and speciation.
Cancer surveys - 1 Jan 1995
Cleaver J E, Speakman J R, Volpe J P
Abstract excerpt
Nucleotide excision repair requires the action of multiple interacting proteins that locate damage in DNA, remove it as a short oligonucleotide and synthesize a replacement patch. Mutations in genes coding for these proteins give rise to a wide range of diseases involving skin carcinogenesis, neuronal decline and developmental disorders of bone and central nervous system. Complex clinical symptoms of more than...
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