Article
Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum.
BMC genomics - 18 Oct 2010
Reilly Ayala Heather B, Wacker Mark A, Siwo Geoffrey, Ferdig Michael T
Abstract excerpt
BACKGROUND: Elevated parasite biomass in the human red blood cells can lead to increased malaria morbidity. The genes and mechanisms regulating growth and development of Plasmodium falciparum through its erythrocytic cycle are not well understood. We previously showed that strains HB3 and Dd2 diverge in their proliferation rates, and here use quantitative trait loci mapping in 34 progeny from a cross between...
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