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Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

7 Oct 2019

Abstract excerpt

Despite intense research and clinical efforts, patients affected by advanced colorectal cancer (CRC) have still a poor prognosis. The discovery of colorectal (CR) cancer stem cell (CSC) as the cell compartment responsible for tumor initiation and propagation may provide new opportunities for the development of new therapeutic strategies. Given the reduced sensitivity of CR-CSCs to chemotherapy and the ability of...

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PMID: 31591478
DOI: 10.1038/s41388-019-1047-4

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