Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic structural rearrangements in genetically engineered mouse mammary tumors.

Genome biology - 1 Jan 2010

Varela Ignacio, Klijn Christiaan, Stephens Phillip J, Mudie Laura J, Stebbings Lucy, Galappaththige Danushka, van der Gulden Hanneke, Schut Eva, Klarenbeek Sjoerd, Campbell Peter J, Wessels Lodewyk Fa, Stratton Michael R, Jonkers Jos, Futreal P Andrew, Adams David J

Abstract excerpt

BACKGROUND: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E-cadherin (Cdh1) mutated lobular breast cancer. RESULTS: We show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Cadherins

Share to Gene Fusion

Share to Gene Rearrangement

Share to Genomic Library

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 20942901
DOI: 10.1186/gb-2010-11-10-r100
PMCID: PMC3218656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic structural rearrangements in genetically engineered mouse mammary tumors.PMID 20942901Read ↗

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.Semantic proximity Read ↗

Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallelsSemantic proximity Read ↗

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancerSemantic proximity Read ↗

Mouse models in the era of large human tumour sequencing studies.Semantic proximity Read ↗

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.Semantic proximity Read ↗

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterpartsSemantic proximity Read ↗

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors.Semantic proximity Read ↗

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancerSemantic proximity Read ↗

Heterogeneity of mammary lesions represent molecular differencesSemantic proximity Read ↗

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneitySemantic proximity Read ↗

Brca1 Mouse Models: Functional Insights and Therapeutic Opportunities.Semantic proximity Read ↗

A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.