Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER<sup>+</sup>breast cancer cells

1 Dec 2011

Abstract excerpt

Advanced breast cancer cells acquire metastatic properties in response to TGFβ. We show here that the expression of c-Myb increases in TGFβ-treated ER (+) breast cancer cells by protein stabilization, transcription activation and release from miR200-dependent down-regulation. In particular, we mapped 2 sites for miR200b, miR200c and miR429 binding in the 3' UTR of the human c-myb gene. These microRNAs decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Cancer Cells and Metastasis
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22101269
DOI: 10.4161/cc.10.23.18346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER<sup>+</sup>breast cancer cellsPMID 22101269Read ↗

Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasisSemantic proximity Read ↗

MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathwaysSemantic proximity Read ↗

Expression of the type III TGF-β receptor is negatively regulated by TGF-βSemantic proximity Read ↗

Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cellsSemantic proximity Read ↗

Gain or loss of TGF-β signaling in mammary carcinoma cells can promote metastasisSemantic proximity Read ↗

The role of c-Myc-RBM38 loop in the growth suppression in breast cancerSemantic proximity Read ↗

MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathwaySemantic proximity Read ↗

MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1FSemantic proximity Read ↗

Silencing of Transforming Growth Factor-β1 <i>In situ</i> by RNA Interference for Breast Cancer: Implications for Proliferation and Migration <i>In vitro</i> and Metastasis <i>In vivo</i>Semantic proximity Read ↗

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.Semantic proximity Read ↗

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.Semantic proximity Read ↗

HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.