Article
Haplotype inferring via galled-tree networks is NP-complete.
Journal of computational biology : a journal of computational molecular cell biology - 1 Oct 2010
Gupta Arvind, Karimi Mohammad M, Manuch Ján, Stacho Ladislav, Zhao Xiaohong
Abstract excerpt
The problem of determining haplotypes from genotypes has gained considerable prominence in the research community since the beginning of the HapMap project. Here the focus is on determining the sets of SNP values of individual chromosomes (haplotypes), since such information better captures the genetic causes of diseases. One of the main algorithmic tools for haplotyping is based on the assumption that the...
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