Article
No association of polymorphisms in the cell polarity gene SCRIB with breast cancer risk.
Breast cancer research and treatment - 1 May 2011
Dünnebier Thomas, Schlaefer Klaus, Gilbert Michael, Baisch Christian, Justenhoven Christina, Brauch Hiltrud, Harth Volker, Spickenheuer Anne, Rabstein Sylvia, Pesch Beate, Brüning Thomas, Ko Yon-Dschun, Hamann Ute
Abstract excerpt
The human homolog of the Drosophila Scribble (SCRIB) tumor suppressor gene encodes a protein that regulates apical-basolateral polarity in mammalian epithelia and controls cell proliferation. Due to the role of cell polarity proteins in human cancers, we investigated whether genetic variability i...
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