Article
PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Martínez-García Ana, Sastre Isabel, Recuero María, Aldudo Jesús, Vilella Elisabet, Mateo Ignacio, Sánchez-Juan Pascual, Vargas Teo, Carro Eva, Bermejo-Pareja Félix, Rodríguez-Rodríguez Eloy, Combarros Onofre, Rosich-Estrago Marcel, Frank Ana, Valdivieso Fernando, Bullido María J
Abstract excerpt
Oxidative stress, which plays a critical role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), is intimately linked to aging, the best established risk factor for AD. Studies in neuronal cells subjected to oxidative stress, mimicking such stress in AD brains, are therefore of great interest. PLA2G3 is the most overexpressed gene in a human neuronal model of oxidative stress...
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