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Article

An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Mar 2011

Chen Xu, Li Yong, Alawi Faizan, Bouchard Jessica R, Kulkarni Ashok B, Gibson Carolyn W

Abstract excerpt

BACKGROUND: Amelogenins are highly conserved proteins secreted by ameloblasts in the dental organ of developing teeth. These proteins regulate dental enamel thickness and structure in humans and mice. Mice that express an amelogenin transgene with a P70T mutation (TgP70T) develop abnormal epithel...

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Identifiers

PMID: 20923441
DOI: 10.1111/j.1600-0714.2010.00940.x
PMCID: PMC3319078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20923441-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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