Article
Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania.
The American journal of tropical medicine and hygiene - 1 Oct 2010
Norton Alice J, Gower Charlotte M, Lamberton Poppy H L, Webster Bonnie L, Lwambo Nicholas J S, Blair Lynsey, Fenwick Alan, Webster Joanne P
Abstract excerpt
Recent shifts in global health policy have led to the implementation of mass drug administration (MDA) for neglected tropical diseases. Here we show how population genetic analyses can provide vital insights into the impact of such MDA on endemic parasite populations. We show that even a single round of MDA produced a genetic bottleneck with reductions in a range of measures of genetic diversity of Schistosoma...
Topics
- Animals
- Child
- Cluster Analysis
- Genetic Variation
- Humans
- Phylogeny
- Praziquantel
- Schistosoma mansoni
- Schistosomiasis mansoni
- Schistosomicides
- Tanzania
- Time Factors