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Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.

Biochimica et biophysica acta - 1 Jan 2011

Eschbach Judith, Fergani Anissa, Oudart Hugues, Robin Jean-Patrice, Rene Frédérique, Gonzalez de Aguilar Jose-Luis, Larmet Yves, Zoll Joffrey, Hafezparast Majid, Schwalenstocker Birgit, Loeffler Jean-Philippe, Ludolph Albert C, Dupuis Luc

Abstract excerpt

The molecular motor dynein is regulated by the huntingtin protein, and Huntington's disease (HD) mutations of huntingtin disrupt dynein motor activity. Besides abnormalities in the central nervous system, HD animal models develop prominent peripheral pathology, with defective brown tissue thermogenesis and dysfunctional white adipocytes, but whether this peripheral phenotype is recapitulated by dynein dysfunction...

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PMID: 20887786
DOI: 10.1016/j.bbadis.2010.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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