Article
The development of handed asymmetry in aggregation chimeras of situs inversus mutant and wild-type mouse embryo.
Development (Cambridge, England) - 1 Nov 1990
Brown N A, McCarthy A, Wolpert L
Abstract excerpt
Mutant iv/iv mice develop as if they have no sense of left and right, so the development of asymmetry is random: half normal, half as a mirror-image of normal, situs inversus. We have made aggregation chimeras of 8-cell stage iv/iv and +/+ embryos, transferred them into pseudopregnant mice, and examined their phenotype on day 10 of gestation. The contribution of mutant and wild-type cells to tissues of the embryo...
Topics
- Animals
- Chimera
- Embryo Transfer
- Functional Laterality
- Genotype
- Mice
- Mice, Inbred Strains
- Mutation