Article
Situs inversus in the developing mouse: proteins affected by the iv mutation (genocopy) and the teratogen retinoic acid (phenocopy).
Molecular reproduction and development - 1 Jun 1991
Van Keuren M L, Layton W M, Iacob R A, Kurnit D M
Abstract excerpt
To decipher genes that are important in the determination of laterality, we compared two-dimensional protein gels from wild-type C57BL/6J mice and C57BL/6J mice that carried the iv mutation, which confers random determination of visceral situs. To span the time period(s) during which laterality determination occurs, we compared computer-analyzed two-dimensional protein gels from wild-type mouse embryos and iv/iv...
Topics
- Animals
- Electrophoresis, Gel, Two-Dimensional
- Embryonic and Fetal Development
- Functional Laterality
- Image Processing, Computer-Assisted
- Mice
- Mice, Inbred C57BL
- Mutation
- Protein Biosynthesis
- Proteins