Article
Size regulation does not cause the composition of mouse chimaeras to become unbalanced.
The International journal of developmental biology - 1 Jan 2001
Tang P C, West J D
Abstract excerpt
Mouse chimaeras made by aggregating two 8-cell stage embryos undergo size regulation shortly after implantation. Thus chimaeric pups are approximately normal size at birth despite their origin from two complete embryos. Chimaeras of some strain combinations are genotypically unbalanced such that cells of one strain almost always predominate. For example, the BALB/c inbred strain often makes a low contribution to...
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