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Article

Germline Variation Controls the Architecture of Somatic Alterations in Tumors

23 Sept 2010

Abstract excerpt

Studies have suggested that somatic events in tumors can depend on an individual's constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and across individuals. Specifically, we performed array comparative genomic hybridization on 104 tumors from 25 unrelated...

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PMID: 20885788
DOI: 10.1371/journal.pgen.1001136

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