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Article

Altering Glypican-1 levels modulates canonical Wnt signaling during trigeminal placode development.

Developmental biology - 1 Dec 2010

Shiau Celia E, Hu Na, Bronner-Fraser Marianne

Abstract excerpt

Glypicans are conserved cell surface heparan sulfate proteoglycans expressed in a spatiotemporally regulated manner in many developing tissues including the nervous system. Here, we show that Glypican-1 (GPC1) is expressed by trigeminal placode cells as they ingress and contribute to trigeminal sensory neurons in the chick embryo. Either expression of full-length or truncated GPC1 in vivo causes defects in...

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Source

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Identifiers

PMID: 20883685
DOI: 10.1016/j.ydbio.2010.09.017
PMCID: PMC4082824

Genes

GPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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