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Article

A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene.

Cellular & molecular biology letters - 1 Dec 2010

Butkiewicz Dorota, Krześniak Małgorzata, Vaitiekunaite Rasa, Sikora Bozena, Bowman Elise D, Harris Curtis C, Rusin Marek

Abstract excerpt

The XPA gene has a commonly occurring polymorphism (G23A) associated with cancer risk. This study assessed the functional significance of this polymorphism, which is localised near the translation start codon. Lymphoblastoid cell lines with alternative homozygous genotypes showed no significant differences in their XPA levels. The luciferase reporter assay detected no functional difference between the two...

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Identifiers

PMID: 20865363
DOI: 10.2478/s11658-010-0032-2
PMCID: PMC6275895

Genes

XPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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