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Article

Substance P enhances Th17 phenotype in individuals with generalized anxiety disorder: an event resistant to glucocorticoid inhibition.

Journal of clinical immunology - 1 Feb 2011

Barros Priscila O, Ferreira Thais B, Vieira Morgana M M, Almeida Carla Renata M, Araújo-Lima Carlos Fernando, Silva-Filho Renato G, Hygino Joana, Andrade Regis M, Andrade Arnaldo F, Bento Cleonice A

Abstract excerpt

Our objective was to evaluate the effect of stress-related dose of substance P (SP) on the in vitro proliferation and cytokine production in polyclonally activated T cells from healthy individuals or individuals with generalized anxiety disorder (GAD). Our results demonstrated that cell cultures from GAD group proliferated less following T cell activation, as compared with control group. The addition of SP...

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PMID: 20865305
DOI: 10.1007/s10875-010-9466-6

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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