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Article

Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice.

PloS one - 16 Sept 2010

Fuss Johannes, Ben Abdallah Nada M B, Hensley Frank W, Weber Klaus-Josef, Hellweg Rainer, Gass Peter

Abstract excerpt

Recent evidence postulates a role of hippocampal neurogenesis in anxiety behavior. Here we report that elevated levels of neurogenesis elicit increased anxiety in rodents. Mice performing voluntary wheel running displayed both highly elevated levels of neurogenesis and increased anxiety in three different anxiety-like paradigms: the open field, elevated O-maze, and dark-light box. Reducing neurogenesis by...

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Identifiers

PMID: 20862278
DOI: 10.1371/journal.pone.0012769
PMCID: PMC2940841

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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