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Contribution of Matrix Metallopeptidase-1 Genotypes, Smoking, Alcohol Drinking and Areca Chewing to Nasopharyngeal Carcinoma Susceptibility.

Anticancer research - 1 Jul 2016

Tsai Chia-Wen, Chang Wen-Shin, Gong Chi-Li, Shih Liang-Chun, Chen Liang-Yu, Lin En-Yuan, Li Hsin-Ting, Yen Shiou-Ting, Wu Cheng-Nan, Bau DA-Tian

Abstract excerpt

BACKGROUND/AIM: The up-regulation of matrix metalloproteinase-1 (MMP-1) has been demonstrated to be correlated with lymph node metastasis of nasopharyngeal carcinoma (NPC); however, the genotypic role of MMP-1 is not well understand. The present study aimed to assess the contribution of MMP-1 promoter -1607 genotypes, combined with environmental carcinogens, on the predisposition to NPC tumorigenesis. MATERIALS...

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PMID: 27354591

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