Article
Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci.
Eukaryotic cell - 1 Aug 2006
Kasama Takashi, Shigehisa Akira, Hirata Aiko, Saito Takamune T, Tougan Takahiro, Okuzaki Daisuke, Nojima Hiroshi
Abstract excerpt
We report here a functional analysis of spo5(+)(mug12(+)) of Schizosaccharomyces pombe, which encodes a putative RNA-binding protein. The disruption of spo5(+) caused abnormal sporulation, generating inviable spores due to failed forespore membrane formation and the absence of a spore wall, as determined by electron microscopy. Spo5 regulates the progression of meiosis I because spo5 mutant cells display normal...
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