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Article

SOHLH1 and SOHLH2 coordinate spermatogonial differentiation.

Developmental biology - 15 Jan 2012

Suzuki Hitomi, Ahn Hyo Won, Chu Tianjiao, Bowden Wayne, Gassei Kathrin, Orwig Kyle, Rajkovic Aleksandar

Abstract excerpt

Spermatogonial self-renewal and differentiation are essential for male fertility and reproduction. We discovered that germ cell specific genes Sohlh1 and Sohlh2, encode basic helix-loop-helix (bHLH) transcriptional regulators that are essential in spermatogonial differentiation. Sohlh1 and Sohlh2 individual mouse knockouts show remarkably similar phenotypes. Here we show that SOHLH1 and SOHLH2 proteins are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22056784
DOI: 10.1016/j.ydbio.2011.10.027
PMCID: PMC3249242

Genes

SOHLH1
SOHLH2
GFRA1
KIT
SOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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