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Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

15 Sept 2010

Abstract excerpt

The epigenome consists of non-sequence-based modifications, such as DNA methylation, that are heritable during cell division and that may affect normal phenotypes and predisposition to disease. Here, we have performed an unbiased genome-scale analysis of ~4 million CpG sites in 74 individuals with comprehensive array-based relative methylation (CHARM) analysis. We found 227 regions that showed extreme...

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PMID: 20844285
DOI: 10.1126/scitranslmed.3001262

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