Article
Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing.
Clinical chemistry and laboratory medicine - 1 Dec 2010
Schwarz Herbert, Stephan Sina, Sidelmann Johannes J, Fischer Bodo, Althaus Harald, Hahn Martin, Kappel Andreas, Ehm Matthias, Vitzthum Frank
Abstract excerpt
BACKGROUND: The Marburg I (MRI) single nucleotide polymorphism (SNP) of the factor VII-activating protease (FSAP) gene has been associated with thrombophilia, thromboembolism, atherosclerosis, and the incidence and progression of carotid stenosis. At present, MRI SNP testing is mainly performed using costly nucleic acid analysis. The ratio between FSAP activity and antigen concentrations in citrated plasma has...
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