Article
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.
Journal of human genetics - 1 Dec 2010
Shimizu Chisato, Matsubara Tomoyo, Onouchi Yoshihiro, Jain Sonia, Sun Shelly, Nievergelt Caroline M, Shike Hiroko, Brophy Victoria H, Takegawa Tsuyoshi, Furukawa Susumu, Akagi Teiji, Newburger Jane W, Baker Annette L, Burgner David, Hibberd Martin L, Davila Sonia, Levin Michael, Mamtani Manju, He Weijing, Ahuja Sunil K, Burns Jane C
Abstract excerpt
Aneurysms of the vascular wall represent a final common pathway for a number of inflammatory processes, including atherosclerosis and idiopathic vasculitis syndromes. Kawasaki disease (KD) is an acute, self-limited vasculitis in children and the leading cause of acquired coronary artery aneurysms. We sought to identify shared molecular mechanisms of aneurysm formation by genotyping eight polymorphisms in matrix...
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