Article
E2-2 protein and Fuchs's corneal dystrophy.
The New England journal of medicine - 9 Sept 2010
Baratz Keith H, Tosakulwong Nirubol, Ryu Euijung, Brown William L, Branham Kari, Chen Wei, Tran Khoa D, Schmid-Kubista Katharina E, Heckenlively John R, Swaroop Anand, Abecasis Goncalo, Bailey Kent R, Edwards Albert O
Abstract excerpt
BACKGROUND: Fuchs's corneal dystrophy (FCD) is a leading cause of corneal transplantation and affects 5% of persons in the United States who are over the age of 40 years. Clinically visible deposits called guttae develop under the corneal endothelium in patients with FCD. A loss of endothelial cells and deposition of an abnormal extracellular matrix are observed microscopically. In advanced disease, the cornea...
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