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Article

Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

PLoS medicine - 31 Aug 2010

Li Shengxu, Zhao Jing Hua, Luan Jian'an, Ekelund Ulf, Luben Robert N, Khaw Kay-Tee, Wareham Nicholas J, Loos Ruth J F

Abstract excerpt

BACKGROUND: We have previously shown that multiple genetic loci identified by genome-wide association studies (GWAS) increase the susceptibility to obesity in a cumulative manner. It is, however, not known whether and to what extent this genetic susceptibility may be attenuated by a physically active lifestyle. We aimed to assess the influence of a physically active lifestyle on the genetic predisposition to...

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Identifiers

PMID: 20824172
DOI: 10.1371/journal.pmed.1000332
PMCID: PMC2930873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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