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Article

Physical activity modifies genetic susceptibility to obesity in postmenopausal women.

Menopause (New York, N.Y.) - 1 Oct 2018

Ochs-Balcom Heather M, Preus Leah, Nie Jing, Wactawski-Wende Jean, Agyemang Linda, Neuhouser Marian L, Tinker Lesley, Zheng Cheng, Kazlauskaite Rasa, Qi Lihong, Sucheston-Campbell Lara E

Abstract excerpt

OBJECTIVE: We conducted a gene-environment interaction study to evaluate whether the association of body mass index (BMI) associated meta genome-wide association study single-nucleotide polymorphisms (SNPs) (as a genetic risk score) and BMI is modified by physical activity and age. METHODS: In 8,206 women of European ancestry from the Women's Health Initiative (WHI), we used linear regression to examine main...

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PMID: 29762199
DOI: 10.1097/GME.0000000000001134
PMCID: PMC6136965

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