Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

doi:10.3945/ajcn.2009.27652

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Article

Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

The American journal of clinical nutrition - 1 Aug 2009

Vimaleswaran Karani S, Li Shengxu, Zhao Jing Hua, Luan Jian'an, Bingham Sheila A, Khaw Kay-Tee, Ekelund Ulf, Wareham Nicholas J, Loos Ruth J F

Abstract excerpt

BACKGROUND: Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity. OBJECTIVE: We examined whether this robust genetic predisposition to obesity can be attenuated by being more physically active. DESIGN: The FTO variant rs1121980 was genotyped in 20,374...

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PMID: 19553294
DOI: 10.3945/ajcn.2009.27652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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