Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Dodgson Andrew R, Dodgson Kirsty J, Pujol Claude, Pfaller Michael A, Soll David R

Abstract excerpt

Population studies have indicated that natural resistance to flucytosine (5FC) in Candida albicans is limited to one of the five major clades, clade I. In addition, while 73% of clade I isolates are less susceptible to 5FC (MIC >/= 0.5 microg/ml), only 2% of non-clade I isolates are less susceptible. In order to determine the genetic basis for this clade-specific resistance, we sequenced two genes involved in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candida albicans

Share to Cysteine

Share to DNA Fingerprinting

Share to Drug Resistance, Fungal

Share to Genes, Fungal

Share to Nucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 15155225
DOI: 10.1128/AAC.48.6.2223-2227.2004
PMCID: PMC415630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans.PMID 15155225Read ↗

Flucytosine Resistance Is Restricted to a Single Genetic Clade of <i>Candida albicans</i>Semantic proximity Read ↗

Mutational Analysis of Flucytosine Resistance in <i>Candida glabrata</i>Semantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

Nonsense and Missense Mutations in <i>FCY2</i> and <i>FCY1</i> Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of <i>Candida lusitaniae</i>Semantic proximity Read ↗

Population Structure and Properties of <i>Candida albicans</i> , as Determined by Multilocus Sequence TypingSemantic proximity Read ↗

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.Semantic proximity Read ↗

Clonal population of flucytosine-resistant Candida tropicalis from blood cultures, Paris, France.Semantic proximity Read ↗

Vulvovaginal <i>candidiasis</i>: species distribution, fluconazole resistance and drug efflux pump gene overexpressionSemantic proximity Read ↗

<i>Candida albicans</i>cladesSemantic proximity Read ↗

Acquisition of Flucytosine, Azole, and Caspofungin Resistance in <i>Candida glabrata</i> Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant RecipientSemantic proximity Read ↗

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazoleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.