Article
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2011
Dave Bhuvanesh, Migliaccio Ilenia, Gutierrez M Carolina, Wu Meng-Fen, Chamness Gary C, Wong Helen, Narasanna Archana, Chakrabarty Anindita, Hilsenbeck Susan G, Huang Jian, Rimawi Mothaffar, Schiff Rachel, Arteaga Carlos, Osborne C Kent, Chang Jenny C
Abstract excerpt
PURPOSE: Phosphatase and tensin homolog (PTEN) loss or activating mutations of phosphoinositol-3 (PI3) kinase (PIK3CA) may be associated with trastuzumab resistance. Trastuzumab, the humanized human epidermal growth factor receptor 2 (HER2) monoclonal antibody, and lapatinib, an epidermal growth...
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