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Article

The sequence polymorphism of MnSOD gene in subjects with respiratory insufficiency in COPD.

Medical science monitor : international medical journal of experimental and clinical research - 1 Sept 2010

Pietras Tadeusz, Szemraj Janusz, Witusik Andrzej, Hołub Monika, Panek Michał, Wujcik Radosław, Górski Paweł

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with the development of respiratory failure, which, in turn, exposes the tissues to oxidative stress, which is both a cause and a result of respiratory insufficiency. The first-line defense against oxidative stress is provided by the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which is a superoxide anion scavenger. It is...

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PMID: 20802415

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